E10ISPM21000KPA Microscopy Camera

Product Introduction

Touptek's new E10ISPM series cameras feature cutting-edge USB3.2 Gen2 technology, breaking through transmission bottlenecks with 10 Gbps high bandwidth, achieving speeds 2-3 times faster than traditional USB3.0 cameras, supporting microscopy imaging, industrial inspection, scientific research and other scenarios. The USB Type-C interface supports reversible insertion, combining convenience with stability to meet multi-device connection requirements.

The series adopts Sony IMX high-performance CMOS sensors, providing excellent low-noise performance and high dynamic range. Supports 8/12-bit data switching to meet diverse needs from rapid preview to precision measurement.

Typical applications: High-speed microscopy imaging, fluorescence imaging, biomedical research, semiconductor inspection, industrial quality control, scientific experiments.

Key Features

  • USB3.2 Gen2 interface with 10 Gbps ultra-high bandwidth, transmission speed 2-3 times faster than USB3.0
  • USB Type-C interface supporting reversible insertion for convenient and stable connection
  • Sony IMX high-performance CMOS sensors (IMX472/IMX383/IMX585) with low noise and high sensitivity
  • Flexible switching between 8/12-bit data formats
  • High frame rate acquisition up to 240 fps@1760×1318 (8-bit)
  • Low readout noise as low as 1.07 e- (HCG mode)
  • High dynamic range up to 72 dB
  • Resolution coverage from 8.3–21 MP meeting diverse application requirements
  • Support for hardware and software binning (2×2, 3×3, 4×4)
  • C-mount standard lens interface compatible with various microscopes and industrial lenses
  • Support for external trigger and GPIO control
  • Bundled ToupView software with Windows/Linux/macOS/Android multi-platform SDK
  • Compliant with CE/FCC certification standards

Product Details

Key Parameters
Model E10ISPM21000KPA
Sensor IMX472 (C,RS)
Effective Pixels / Resolution 21M (5280×3956)
Frame Rate (Full Resolution) 49 fps@5280×3956(8-bit); 25 fps@5280×3956(12-bit); 115 fps@2640×1978(8-bit); 55 fps@2640×1978(12-bit); 240 fps@1760×1318(8-bit); 117 fps@1760×1318(12-bit)
Shutter Type Rolling Shutter
Color Type Color
Imaging Performance
Pixel Size 3.3 µm × 3.3 µm
Sensor Size 17.42 mm × 13.05 mm
Diagonal 1.36" (21.77 mm)
Dynamic Range 72 dB
Bit Depth 8/12-bit
Sensitivity 400 mV with 1/30s; 0.1 mV with 1/30s
Read Noise 4.58 e-
Full Well Capacity 24,600 e-
Signal-to-Noise Ratio 43.9 dB
Conversion Gain 6.017 e-/ADU
Interface & Mechanical
Data Interface USB3.2 Gen2 (Type-C)
GPIO 1 optically isolated input, 1 optically isolated output, 2 non-isolated input/output ports
Lens Mount C-mount
Binning Mode Hardware 2×2, 3×3, 4×4; Software 2×2, 3×3, 4×4
Dimensions TBD
Weight TBD
Power Supply USB Type-C interface power
Environment & Certification
Operating Temperature / Humidity -10 °C ~ +50 °C / 20%~80%RH
Storage Temperature / Humidity -30 °C ~ +70 °C / 10%~60%RH
Operating System Windows/Linux/macOS/Android multi-platform SDK (native C/C++, C#/VB.NET, Python, Java, DirectShow, TWAIN, etc.)
Certification CE, FCC

Product Overview

E10ISPM21000KPA is a professional microscopy camera featuring USB3.2 Gen2 high-speed transmission technology, equipped with the high-performance IMX472 (C,RS) image sensor with the following characteristics:

  • 10 Gbps Ultra-High Bandwidth: USB3.2 Gen2 interface provides 10 Gbps transmission bandwidth, 2-3 times faster than traditional USB3.0, breaking through data transmission bottlenecks and achieving high-speed imaging at 21M (5280×3956) resolution
  • Type-C Convenient Connection: USB Type-C interface supports reversible insertion, more convenient and stable connection, adapts to multi-device connectivity requirements, compatible with modern laboratories and industrial environments
  • Outstanding Image Quality: 21M (5280×3956) resolution, 3.3 µm × 3.3 µm pixel size, sensor size of 17.42 mm × 13.05 mm , ensuring clear detail presentation
  • High-Speed Data Transmission: Maximum frame rate up to 49 fps@5280×3956(8-bit); 25 fps@5280×3956(12-bit); 115 fps@2640×1978(8-bit); 55 fps@2640×1978(12-bit); 240 fps@1760×1318(8-bit); 117 fps@1760×1318(12-bit) , fully leveraging the 10 Gbps bandwidth advantage, supporting real-time preview and rapid capture
  • Ultra-Low Noise Performance: Read noise as low as 4.58 e-, full well capacity 24,600 e- , signal-to-noise ratio up to 43.9 dB, suitable for low-light and fluorescence imaging
  • Flexible Imaging Modes: 8/12-bit bit depth switching, dynamic range up to 72 dB , supports hardware and software binning (2×2, 3×3, 4×4)
  • Optical Compatibility: Standard C-mount interface, compatible with various microscope brands, optional 0.5X/0.63X/1X adapters available
  • Compact Design: Dimensions only TBD , weight TBD , powered by USB Type-C interface power , no external power supply required
  • Software Support: Includes professional microscopy imaging software ToupView, supports Windows/Linux/macOS/Android multi-platform SDK (native C/C++, C#/VB.NET, Python, Java, DirectShow, TWAIN, etc.) systems, provides measurement, annotation, stitching, focus stacking and other functions, supports C/C++, C#, Python, ImageJ, μManager and other development environments

Core Performance Indicators

Resolution

21M (5280×3956)

Frame Rate

49 fps@5280×3956(8-bit)

Transmission Bandwidth

10 Gbps

Data Interface

USB3.2 Gen2 (Type-C)

Professional Microscopy Imaging Features

High-Speed Transmission Advantage

USB3.2 Gen2 technology provides 10 Gbps bandwidth, enabling smooth preview and rapid data transmission at high resolution, particularly suitable for dynamic observation and large-scale data collection

Research-Grade Image Quality

Low read noise and high dynamic range design ensure clear, accurate microscopy images under various lighting conditions, meeting research-level application requirements

Type-C Convenient Connection

USB Type-C interface supports reversible insertion, stable and reliable connection, compatible with modern laboratory equipment, simplifying system integration

Flexible Imaging Control

Supports various binning modes and ROI selection, 8/12-bit data switching, meeting diverse needs from rapid preview to precise measurement

Recommendation

The E10ISPM21000KPA microscopy camera, with its USB3.2 Gen2 10 Gbps ultra-high bandwidth, outstanding image quality, and convenient Type-C connection, is the ideal choice for high-speed microscopy imaging. Whether for biomedical research, material analysis, or industrial inspection, it provides fast, clear, and reliable microscopy image recording and analysis solutions, particularly suitable for professional applications requiring high-speed data transmission and real-time observation.

E10ISPM21000KPA Product Manual

PDF format, including detailed technical parameters and dimensional drawings


SDK Development Kit

Supporting Windows, Linux, macOS and other platforms


3D Model Files

STEP format for mechanical design integration

Package Contents #

Standard configuration and packing details for E10ISPM series USB 3.2 Gen2 hardware ISP CMOS cameras

Standard Packing List
  1. Outer carton: L 52 cm × W 32 cm × H 33 cm (20 pcs, approximately 12-17 kg per carton)
  2. Inner box: L 15 cm × W 15 cm × H 10 cm (0.58-0.60 kg per box)
  3. One E10ISPM series camera
  4. High-speed USB 3.2 dual Type-C gold-plated data cable (2.0 m)
  5. CD (drivers and application software, Ø 12 cm)
Optional Accessories
  1. Adjustable eyepiece tube adapters
    Dia. 23.2 mm eyepiece tube to C-mount: 108001/AMA037, 108002/AMA050, 108003/AMA075, 108004/AMA100
    Dia. 31.75 mm eyepiece tube to C-mount: 108008/ATA037, 108009/ATA050, 108010/ATA075, 108011/ATA100
  2. Fixed eyepiece tube adapters
    Dia. 23.2 mm eyepiece tube to C-mount: 108005/FMA037, 108006/FMA050, 108007/FMA075, 108008/FMA100
    Dia. 31.75 mm eyepiece tube to C-mount: 108011/FTA037, 108012/FTA050, 108013/FTA075, 108014/FTA100
  3. 108015 (Dia. 23.2 mm to 30.0 mm ring) - adapter ring for 30 mm eyepiece tubes
  4. 108016 (Dia. 23.2 mm to 30.5 mm ring) - adapter ring for 30.5 mm eyepiece tubes
  5. 108017 (Dia. 23.2 mm to 31.75 mm ring) - adapter ring for 31.75 mm eyepiece tubes
  6. Stage micrometers
    106011/TS-M1 (X = 0.01 mm/100 Div.)
    106012/TS-M2 (X, Y = 0.01 mm/100 Div.)
    106013/TS-M7 (X = 0.01 mm/100 Div., 0.10 mm/100 Div.)
Note: The E10ISPM series leverages USB 3.2 Gen2 technology with data rates up to 10 Gbps. For options F and G, confirm your camera model (C-mount microscope or telescope camera) so the ToupTek Photonics engineering team can recommend the most suitable adapter.
Standard packing list; actual accessories follow the enclosed packing slip.

Product Dimensions #

Outline reference for E10ISPM series USB 3.2 Gen2 hardware ISP CMOS cameras

E10ISPM series dimensions
E10ISPM Series
USB 3.2 Gen2 Outline drawing
E10ISPM series camera dimensions
Click the image to view the full-size diagram.

Frequently Asked Questions

Understand the professional capabilities of the E10ISPM series microscopy imaging cameras

The E10ISPM series is a USB 3.2 Gen2 hardware ISP microscopy camera family launched by ToupTek Photonics. It integrates Sony IMX back-illuminated CMOS sensors with an onboard 12-bit ISP pipeline to deliver low-noise, high-dynamic-range images directly from the microscope. The 10 Gbps data channel enables high-resolution capture and real-time preview, supporting fluorescence, bright-field, and high-speed scientific imaging tasks.

  • 10 Gbps bandwidth: Doubles the throughput of USB 3.0 (5 Gbps) and eliminates transmission bottlenecks.
  • Sustained high frame rates: 21 MP sensors still reach 49 fps, while 8.3 MP models deliver up to 88 fps at 8-bit output.
  • Reversible Type-C interface: Reliable connections with plug-from-any-side convenience and stronger mechanical retention.
  • Lower latency: Minimizes transfer delays for true real-time preview and rapid acquisition.
  • Backward compatibility: Fully compatible with USB 3.0 and USB 2.0 systems to protect existing investments.

Resolution range: 8.3 MP to 21 MP to match different microscopy scenarios.

Read noise: As low as 1.07 e⁻ in HCG mode for fluorescence and other low-light imaging.

Dynamic range: Up to 72 dB, preserving highlight detail and shadow gradations.

Signal-to-noise ratio: Up to 45.9 dB for clean, high-contrast imagery.

Bit-depth options: Switchable 8/10/12-bit output to balance speed and accuracy.

Binning modes: Hardware and software 2×2/3×3/4×4 binning for sensitivity boosts.

The series is widely used for high-speed microscopy imaging, live-cell observation, GFP/RFP/DAPI fluorescence capture, time-lapse experiments, semiconductor wafer inspection, materials surface analysis, industrial quality control, pathology slide digitization, and research or teaching deployments that require fast data pipelines.

Transfer speed: USB 3.2 Gen2 provides 10 Gbps bandwidth—double that of E3ISPM’s USB 3.0 interface.

Interface update: Type-C connectivity offers reversible plug-in and sturdier connectors.

Image quality: Lower read noise and higher SNR deliver cleaner scientific imagery.

Frame-rate benefit: Higher throughput supports faster preview and acquisition at identical resolutions.

Future readiness: Additional bandwidth reserves capacity for next-generation high-resolution sensors.

E10ISPM21000KPA: 21 MP, 4/3-inch format, delivering the largest field of view for high-resolution inspection.

E10ISPM20000KPA: 20 MP, 1/1.1-inch format, a balanced choice for mainstream microscopy workflows.

E10ISPM08300KPA: 8.3 MP, featuring 1.07 e⁻ minimum read noise, optimized for fluorescence and fast dynamics.

Consider resolution, field-of-view requirements, frame-rate targets, sensitivity demands, and budget constraints when selecting a model.

In-Depth Product Introduction

USB 3.2 Gen2 10 Gbps Data Throughput

E10ISPM cameras adopt the latest USB 3.2 Gen2 standard, providing 10 Gbps theoretical bandwidth and more than 8 Gbps effective transmission. Compared with the 5 Gbps ceiling of USB 3.0, throughput increases by 100%, eliminating the bottleneck when streaming ultra-high-resolution data. Even at 21 MP full resolution the camera maintains 49 fps at 8-bit output, while the 8.3 MP model reaches up to 88 fps, delivering both high resolution and high frame rate.

USB Type-C Convenient Connectivity

The USB Type-C connector supports reversible plug-in, ending the trial-and-error associated with legacy connectors. Reinforced mechanical strength and improved electrical characteristics provide a reliable link and sufficient power delivery without an additional adapter. Type-C is widely compatible; simple adapters allow seamless integration with traditional USB-A workstations.

Sony IMX High-Performance CMOS Sensors

The series employs Sony’s latest IMX sensors, including IMX472 (21 MP), IMX383 (20 MP), and IMX585 (8.3 MP). These sensors combine advanced fabrication with superb quantum efficiency to minimize read noise—down to 1.07 e⁻ on the IMX585. Dual HCG/LCG gain modes keep noise low while providing a 39,000 e⁻ full well and up to 72 dB dynamic range for demanding scientific imaging.

Professional-Grade Imaging Performance

All models support selectable 8/10/12-bit outputs. Twelve-bit mode offers 4,096 tonal levels for quantitative analysis, whereas 8-bit mode maximizes frame rate for live observation. Carefully tuned gain conversion, read noise, and full well capacity yield up to 45.9 dB SNR, preserving fine detail across a broad range of illumination conditions.

Flexible Imaging Control System

Hardware and software binning (2×2/3×3/4×4) enhance sensitivity and frame rate when required. Programmable ROI capture lets users crop any window to further accelerate acquisition. Exposure can be controlled from microseconds to tens of seconds, and trigger, strobe, and synchronization ports simplify integration with automation platforms.

Robust System Integration & Software Ecosystem

E10ISPM cameras include a comprehensive SDK covering Windows, macOS, Linux, and Android, along with sample code for C/C++, C#, Python, and LabVIEW. Combined with ToupView/XCamView software, the platform supports live measurement, fluorescence pseudo-color, time-lapse capture, focus stacking, stitching, and batch automation to match laboratory, industrial, and educational workflows.

Applications

E10ISPM series deployments across diverse microscopy imaging fields

Key Advantages of the E10ISPM Series

10 Gbps Bandwidth

USB 3.2 Gen2 ultra-high-speed transfer

Type-C Interface

Reversible plug design for easy, stable connections

Sony IMX Sensors

High-performance CMOS with low noise

High Frame Rates

21 MP @ 49 fps; 8.3 MP @ 88 fps

Ultra-Low Noise

Read noise down to 1.07 e⁻

72 dB Dynamic Range

Rich tonal detail with wide latitude

Flexible Binning

Hardware/software 2×2/3×3/4×4 modes

Cross-Platform SDK

Windows, Linux, macOS, and Android support