For fluorescence application, high sensitivity sensor cameras are required. In case the exposure time is only a few seconds, non-cooling camera is enough. E3ISPM and E3CMOS cameras are very suitable. Users could select different model according to its sensitivity parameters. But if the signals are very weak and very long time exposure is required, for example 2 minutes, cooling camera is required. When the cooling camera is set to low temperature (normally 0 degree to 5 degree is enough), during the long time exposure, the noise caused by dark current and temperature will be kept at a very low level and images acquired form the camera can be very clean.
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